23 drug efflux one of the most studied mechanisms of cancer drug resistance involves reducing drug accumulation by enhancing efflux members of the atp binding cassette abc transporter family proteins enable this efflux and are important well studied regulators at the plasma membranes of healthy cells. The cells of most patients cancers are resistant to a class of drugs called proteasome inhibitors that should kill them when studied in the lab these drugs are highly effective yet hundreds . Now scientists may have solved the mystery of these cells surprising hardiness the key resistant cancer cells have shifted how and where they generate their energy using this new insight researchers have identified a drug that resensitizes cancer cells to proteasome inhibitors and pinpointed a gene that is crucial for that susceptibility. Drug resistance in cancer cells cancer cells can acquire resistance to chemotherapy by a range of mechanisms including the mutation or overexpression of the drug target inactivation of the drug
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